Two Research REPORTS on how Trehalose Benefits
Bipolar, Sanfillipo Syndrome, and Muscular Dystrophy
Glycoscience NEWS Lesson #3 for 2020
by JC Spencer
January 2020 – A biopharmaceutical company asked for US and EU government approval for additional testing of the sugar Trehalose for neurological benefits including Sanfillipo syndrome. They reference success in other neurological diseases including muscular dystrophy. Meanwhile, a paper has just been published of the results of studies conducted on Trehalose at the Barcelona University in Spain.
Ongoing research on bipolar disorders is to determine the efficacy and safety of antidepressant drug treatment. Current evidence for the use of antidepressant drugs is lacking even when combined with mood stabilizers. There is a world-wide need to discover a better way to treat depression and specifically bipolar depression.
The sugar Trehalose protects cells from hypoxic and anoxic injury and suppresses protein aggregation. The misfolding of proteins is the cause of or the accentuation of all neurological challenges including Alzheimer’s, Parkinson’s, ALS, and MS.
In vivo studies Trehalose showed cellular and behavioral beneficial effects in animal models of neurodegenerative diseases. Trehalose also provided enhanced autophagy and appeared to have antidepressant results that induce positive behavioral changes.
Trehalose also increases the lithium effects in mice. Based on this hypothesis, the University of Barcelona bipolar project plans to conduct a followup study to determine the efficacy and tolerability of the sugar Trehalose to treat bipolar depression.
The biopharmaceutical company, Seelos Therapeutics is seeking development of therapeutic drugs to address central nervous system disorders and rare diseases. They announced an update to its development programs for SLS-005 (trehalose) in Europe and the U.S.
“We are truly excited to be working with the EMA to formulate the Sanfilippo study in the EU”, said Raj Mehra, Ph.D., Chairman and CEO of Seelos, “there are currently no approved therapies in the EU for this devastating neurological condition.”
In 2018 researchers at the Baylor College of Medicine in Houston said their study was the first report of where THE TREHALOSE EFFECT is quantified for the amount of Trehalose that crosses the blood-brain barrier and activates TFEB (a transcription factor master regulator) in the brain. In turn, TFEB activated the lysosomal system, which led to enhanced clearance of material accumulation, reduced neuroinflammation, retinal degeneration and vision loss and extended lifespan. The retina improvement is significant because loss of vision is a devastating aspect of lysosomal diseases.
References:
https://clinicaltrials.gov/
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