Baylor College of Medicine Report – Study confirms Trehalose
increases cell waste disposal and supports neurological function
Texas Endowment for Medical Research Glycoscience Lesson – Mucopolysaccharidosis
Houston – Simple sugar delays neurodegeneration caused by enzyme deficiency is the title of research released 6/20/2018 by Baylor College of Medicine in collaboration with Texas Children’s Hospital. Published in the journal Autophagy, the research explains that the sugar Trehalose increases the disposal of cellular waste to diminish neurological symptoms in a mouse model of the disease mucopolysaccharidoses IIIB (MPS IIIB).
Three types of mucopolysaccharidosis, also called glycosaminoglycans, affect children. The cause is a deficiency of an enzyme needed to break down some long chain sugars. Mucopolysaccharides may be found throughout the body, often as mucus and fluid around the joints. Symptoms range from respiratory infections to buildup of fluid in the brain, heart valve abnormalities, enlarged liver and spleen, enlarged tongue resulting in damaged vocal cords, narrowed airways, and vision impairment. Some children have short stature and joint deformities that affect mobility. Damage to organs and tissues may cause a decline in intellectual function and an irregularly modulated immune system and a shortened lifespan.
The research team tested their approach on a mouse model of MPS IIIB. These mice had a mutation that resulted in most of the clinical symptoms observed in patients including progressive neurodegeneration, loss of vision, brain inflammation and shorter lifespan.
The study results were impressive. “The MPS IIIB mice treated with trehalose lived longer, improved their hyperactive behavior and delayed several neuropathological features, most notably the retinal degeneration, when compared with MPS IIIB mice not treated with trehalose.”
The researchers expressed that someday this therapy may be available to humans but will be limited because, “… this approach faces challenges such as having limited ability to cross the blood-brain barrier and reaching the brain areas where the enzyme is needed.”
This is the first report where THE TREHALOSE EFFECT indicates the amount of Trehalose needed to cross the blood-brain barrier and activate TFEB (a transcription factor master regulator) in the brain. In turn, TFEB activated the lysosomal system, which led to enhanced clearance of material accumulation, reduced neuroinflammation, retinal degeneration, vision loss, and extended lifespan. The retina improvement is significant because loss of vision is a devastating aspect of lysosomal diseases. This is the first preclinical study that shows possible delay of retinal degeneration and loss of vision in the MPS IIIB mouse model.
It is well established that applied Natural Glycoscience can increase cell stability, dislodge cell waste, and delay neurodegeneration that benefit those with neurological challenges. But it would be considered a major medical breakthrough if we can couple these findings with the ability to literally “flush waste out of the brain.”
To flush waste out of the brain IS a possibility. Texas Endowment for Medical Research is concentrating on neurological benefits found from specific sugars. Universities and researchers from as many as fourteen countries have collaborated or cooperated with us in gathering Glycoscience evidence.
During the last several years I have received inquiries from families in different countries who have children with the rare mucopolysaccharidosis disease called Sanfilippo syndrome. This is one of the neurological challenges that Texas Endowment for Medical Research wishes to study further. We are conducting several neurological Pilot Surveys and invite participation.
References:
https://ghr.nlm.nih.gov/condition/mucopolysaccharidosis-type-i
https://medlineplus.gov/ency/article/002263.htm
http://www.endowmentmed.org/pdf/SmartLesson66.pdf
For more information
To Kill A Rat by JC Spencer – http://ToKillARatBOOK.com
Order Glycoscience 101 book from Amazon
http://www.OneSmartSugar.com
© Copyrighted 2018 by JC Spencer [email protected]
Texas Endowment for Medical Research, Inc.
PO Lock Box 73089, Houston, Texas 77273
http://TexasEndowment.org 281-587-2020